Antibiotic development pipeline runs dry

Delving into the Dry - Eye Pipeline

After years of fi ts and starts, the often stalled but always prodigious machinery of the dryeye pipeline appears to be moving forward. Thanks to improvements in designing clinical trials, monitoring patients’ signs and symptoms and evaluating the performance of therapeutic agents, a number of drugs are making their way through the clinical trial process. These agents include new mucomimetics, ...

Antimalaria Drug Development & Pipeline

Artemisin traditionally cleave the peroxide bond by Fe(II) found in heme proteins, thus generating toxic oxygen radicals. Synthetic peroxides, thus are proving to be useful substitutes for artemisinin. The first-generation ozonide OZ277, known as arterolane [1], has been found to inhibit the growth of chloroquine-resistant (K1) and chloroquine sensitive (NF54) parasite strains. In 2012, the com...

Antibiotic dry cow therapy: where next?

Alzheimer's drug-development pipeline: 2016

BACKGROUND Alzheimer's disease (AD) is growing in frequency and new therapies are urgently needed. METHODS We assessed clinicaltrials.gov (accessed 1-4-2016) to determine the number and characteristics of trials in phase I, phase II, and phase III for treatment of AD. RESULTS There are currently 24 agents in 36 trials in phase III of AD drug development. Seven of these 24 agents are symptom...

When Short Runs Beat Long Runs

What will yield the best results: doing one run n generations long or doing m runs n/m generations long each? This paper presents a techniqueindependent analysis which answers this question, and has direct applicability to scheduling and restart theory in evolutionary computation and other stochastic methods. The paper then applies this technique to three problem domains in genetic programming....